All drug half-life profiles

Every entry below links to a dedicated page with a half-life calculator, basic pharmacokinetic summary, and references. Values are approximate and for educational use only.

Drug	Category	Mean half-life
1,4-Butanediol	depressant	0.9 h
2C-B	psychedelic	3 h
Alcohol	depressant	2.5 h
Alprazolam	benzodiazepine	12 h
Amphetamine	stimulant	11 h
Ayahuasca	psychedelic	3 h
Caffeine	stimulant	5 h
CBD	cannabinoid	18 h
Clonazepam	benzodiazepine	34 h
Clonidine	alpha-2-agonist	12 h
Cocaine	stimulant	1 h
Codeine	opioid	3 h
Codeine-promethazine syrup	opioid-combo	3 h
Dextromethorphan	dissociative	3.5 h
Diazepam	benzodiazepine	30 h
DMT	psychedelic	0.3 h
Etizolam	thienodiazepine	3.5 h
Fentanyl	opioid	7 h
Gabapentin	gabapentinoid	7 h
GBL	depressant	0.5 h
GHB	depressant	0.75 h
Heroin	opioid	0.1 h
Hydrocodone	opioid	4 h
Ketamine	dissociative	2.5 h
Kratom	atypical-opioid	23 h
Lorazepam	benzodiazepine	14 h
LSD	psychedelic	3.5 h
MDA	entactogen	10 h
MDMA	entactogen	8 h
MDMB-class synthetic cannabinoids	synthetic-cannabinoid	3 h
Mephedrone	stimulant	2.5 h
Methamphetamine	stimulant	11 h
Methylphenidate	stimulant	3 h
Modafinil	wakefulness-promoting	12 h
Morphine	opioid	2 h
MXE	dissociative	3 h
Nicotine	stimulant	2 h
Nitrous oxide	dissociative	0.25 h
Norketamine	dissociative-metabolite	4 h
Oxycodone	opioid	3.5 h
PCP	dissociative	21 h
Phenibut	gabaergic	8 h
Pregabalin	gabapentinoid	6 h
Psilocybin	psychedelic	3 h
Tapentadol	opioid	5 h
THC	cannabinoid	25 h
Tianeptine	atypical-antidepressant	2.5 h
Tramadol	opioid	6 h
Zolpidem	sedative-hypnotic	2.5 h
Zopiclone / Eszopiclone	sedative-hypnotic	5 h