All drug half-life profiles
Each entry links to a dedicated page with a half-life calculator, a brief pharmacokinetic summary, and source links. Values are approximate and for educational use only.
| Drug | Category | Mean half-life | Summary |
|---|---|---|---|
| 1,4-Butanediol | depressant | 0.9 h | Educational half-life profile for 1,4-Butanediol (depressant). Uses a mean half-life of 0.9 hours for a simplified curve. |
| 2C-B | psychedelic | 3 h | Educational half-life profile for 2C-B (psychedelic). Uses a mean half-life of 3.0 hours for a simplified curve. |
| Alcohol | depressant | 2.5 h | Educational half-life profile for Alcohol (depressant). Uses a mean half-life of 2.5 hours for a simplified curve. |
| Alprazolam | benzodiazepine | 12 h | Educational half-life profile for Alprazolam (benzodiazepine). Uses a mean half-life of 12.0 hours for a simplified curve. |
| Amphetamine | stimulant | 11 h | Educational half-life profile for Amphetamine (stimulant). Uses a mean half-life of 11.0 hours for a simplified curve. |
| Ayahuasca | psychedelic | 3 h | Educational half-life profile for Ayahuasca (psychedelic). Uses a mean half-life of 3.0 hours for a simplified curve. |
| Caffeine | stimulant | 5 h | Educational half-life profile for Caffeine (stimulant). Uses a mean half-life of 5.0 hours for a simplified curve. |
| CBD | cannabinoid | 18 h | Educational half-life profile for CBD (cannabinoid). Uses a mean half-life of 18.0 hours for a simplified curve. |
| Clonazepam | benzodiazepine | 34 h | Educational half-life profile for Clonazepam (benzodiazepine). Uses a mean half-life of 34.0 hours for a simplified curve. |
| Clonidine | alpha-2-agonist | 12 h | Educational half-life profile for Clonidine (alpha-2-agonist). Uses a mean half-life of 12.0 hours for a simplified curve. |
| Cocaine | stimulant | 1 h | Educational half-life profile for Cocaine (stimulant). Uses a mean half-life of 1.0 hours for a simplified curve. |
| Codeine | opioid | 3 h | Educational half-life profile for Codeine (opioid). Uses a mean half-life of 3.0 hours for a simplified curve. |
| Codeine-promethazine syrup | opioid-combo | 3 h | Educational half-life profile for Codeine-promethazine syrup (opioid-combo). Uses a mean half-life of 3.0 hours for a simplified curve. |
| Dextromethorphan | dissociative | 3.5 h | Educational half-life profile for Dextromethorphan (dissociative). Uses a mean half-life of 3.5 hours for a simplified curve. |
| Diazepam | benzodiazepine | 30 h | Educational half-life profile for Diazepam (benzodiazepine). Uses a mean half-life of 30.0 hours for a simplified curve. |
| DMT | psychedelic | 0.3 h | Educational half-life profile for DMT (psychedelic). Uses a mean half-life of 0.3 hours for a simplified curve. |
| Etizolam | thienodiazepine | 3.5 h | Educational half-life profile for Etizolam (thienodiazepine). Uses a mean half-life of 3.5 hours for a simplified curve. |
| Fentanyl | opioid | 7 h | Educational half-life profile for Fentanyl (opioid). Uses a mean half-life of 7.0 hours for a simplified curve. |
| Gabapentin | gabapentinoid | 7 h | Educational half-life profile for Gabapentin (gabapentinoid). Uses a mean half-life of 7.0 hours for a simplified curve. |
| GBL | depressant | 0.5 h | Educational half-life profile for GBL (depressant). Uses a mean half-life of 0.5 hours for a simplified curve. |
| GHB | depressant | 0.75 h | Educational half-life profile for GHB (depressant). Uses a mean half-life of 0.75 hours for a simplified curve. |
| Heroin | opioid | 0.1 h | Educational half-life profile for Heroin (opioid). Uses a mean half-life of 0.1 hours for a simplified curve. |
| Hydrocodone | opioid | 4 h | Educational half-life profile for Hydrocodone (opioid). Uses a mean half-life of 4.0 hours for a simplified curve. |
| Ketamine | dissociative | 2.5 h | Educational half-life profile for Ketamine (dissociative). Uses a mean half-life of 2.5 hours for a simplified curve. |
| Kratom | atypical-opioid | 23 h | Educational half-life profile for Kratom (atypical-opioid). Uses a mean half-life of 23.0 hours for a simplified curve. |
| Lorazepam | benzodiazepine | 14 h | Educational half-life profile for Lorazepam (benzodiazepine). Uses a mean half-life of 14.0 hours for a simplified curve. |
| LSD | psychedelic | 3.5 h | Educational half-life profile for LSD (psychedelic). Uses a mean half-life of 3.5 hours for a simplified curve. |
| MDA | entactogen | 10 h | Educational half-life profile for MDA (entactogen). Uses a mean half-life of 10.0 hours for a simplified curve. |
| MDMA | entactogen | 8 h | Educational half-life profile for MDMA (entactogen). Uses a mean half-life of 8.0 hours for a simplified curve. |
| MDMB-class synthetic cannabinoids | synthetic-cannabinoid | 3 h | Educational half-life profile for MDMB-class synthetic cannabinoids (synthetic-cannabinoid). Uses a mean half-life of 3.0 hours for a simplified curve. |
| Mephedrone | stimulant | 2.5 h | Educational half-life profile for Mephedrone (stimulant). Uses a mean half-life of 2.5 hours for a simplified curve. |
| Methamphetamine | stimulant | 11 h | Educational half-life profile for Methamphetamine (stimulant). Uses a mean half-life of 11.0 hours for a simplified curve. |
| Methylphenidate | stimulant | 3 h | Educational half-life profile for Methylphenidate (stimulant). Uses a mean half-life of 3.0 hours for a simplified curve. |
| Modafinil | wakefulness-promoting | 12 h | Educational half-life profile for Modafinil (wakefulness-promoting). Uses a mean half-life of 12.0 hours for a simplified curve. |
| Morphine | opioid | 2 h | Educational half-life profile for Morphine (opioid). Uses a mean half-life of 2.0 hours for a simplified curve. |
| MXE | dissociative | 3 h | Educational half-life profile for MXE (dissociative). Uses a mean half-life of 3.0 hours for a simplified curve. |
| Nicotine | stimulant | 2 h | Educational half-life profile for Nicotine (stimulant). Uses a mean half-life of 2.0 hours for a simplified curve. |
| Nitrous oxide | dissociative | 0.25 h | Educational half-life profile for Nitrous oxide (dissociative). Uses a mean half-life of 0.25 hours for a simplified curve. |
| Norketamine | dissociative-metabolite | 4 h | Educational half-life profile for Norketamine (dissociative-metabolite). Uses a mean half-life of 4.0 hours for a simplified curve. |
| Oxycodone | opioid | 3.5 h | Educational half-life profile for Oxycodone (opioid). Uses a mean half-life of 3.5 hours for a simplified curve. |
| PCP | dissociative | 21 h | Educational half-life profile for PCP (dissociative). Uses a mean half-life of 21.0 hours for a simplified curve. |
| Phenibut | gabaergic | 8 h | Educational half-life profile for Phenibut (gabaergic). Uses a mean half-life of 8.0 hours for a simplified curve. |
| Pregabalin | gabapentinoid | 6 h | Educational half-life profile for Pregabalin (gabapentinoid). Uses a mean half-life of 6.0 hours for a simplified curve. |
| Psilocybin | psychedelic | 3 h | Educational half-life profile for Psilocybin (psychedelic). Uses a mean half-life of 3.0 hours for a simplified curve. |
| Tapentadol | opioid | 5 h | Educational half-life profile for Tapentadol (opioid). Uses a mean half-life of 5.0 hours for a simplified curve. |
| THC | cannabinoid | 25 h | Educational half-life profile for THC (cannabinoid). Uses a mean half-life of 25.0 hours for a simplified curve. |
| Tianeptine | atypical-antidepressant | 2.5 h | Educational half-life profile for Tianeptine (atypical-antidepressant). Uses a mean half-life of 2.5 hours for a simplified curve. |
| Tramadol | opioid | 6 h | Educational half-life profile for Tramadol (opioid). Uses a mean half-life of 6.0 hours for a simplified curve. |
| Zolpidem | sedative-hypnotic | 2.5 h | Educational half-life profile for Zolpidem (sedative-hypnotic). Uses a mean half-life of 2.5 hours for a simplified curve. |
| Zopiclone / Eszopiclone | sedative-hypnotic | 5 h | Educational half-life profile for Zopiclone / Eszopiclone (sedative-hypnotic). Uses a mean half-life of 5.0 hours for a simplified curve. |