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Substance categories

Categories are broad navigation groups. They help readers compare curve shapes without implying a clinical recommendation, legal status, safety ranking, or shared risk profile.

What categories are for

HalfLifeDB categories help readers find related profiles and compare the representative half-life values used by the calculators. They are deliberately humble labels: useful for browsing, too blunt for decision making.

A category can contain substances with very different routes, metabolites, formulations, and study evidence. This directory keeps those small groups together instead of creating thin category pages. Open the individual profile when you need source links, checkpoint tables, and notes about uncertainty.

How to compare entries

Compare half-life values only after checking what the value represents. A parent compound, metabolite, terminal phase, effective half-life, or formulation-specific estimate can answer different questions. When a profile has enough direct evidence, HalfLifeDB uses one labeled representative value so its curve stays readable. Evidence-note profiles appear without a half-life rather than displaying a proxy.

The site does not use categories to suggest use, purchase, dosing, testing, or safety decisions. The educational focus is pharmacokinetic interpretation: what a simple curve shows, where it breaks down, and where source context should be checked.

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alpha 2 agonist

1 profile currently published.

SubstanceRepresentative half-lifeSources
Clonidine12 h2

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antidepressant

6 profiles currently published.

SubstanceRepresentative half-lifeSources
Venlafaxine5 h3
Trazodone7 h3
Bupropion21 h3
Sertraline26 h3
Escitalopram30 h3
Fluoxetine4.0 days3

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antihistamine

3 profiles currently published.

SubstanceRepresentative half-lifeSources
Diphenhydramine9 h3
DoxylamineNo curve published3
HydroxyzineNo curve published3

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antipsychotic

1 profile currently published.

SubstanceRepresentative half-lifeSources
Quetiapine6 h3

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atypical antidepressant

1 profile currently published.

SubstanceRepresentative half-lifeSources
Tianeptine2.5 h3

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atypical opioid

1 profile currently published.

SubstanceRepresentative half-lifeSources
Kratom23 h3

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benzodiazepine

7 profiles currently published.

SubstanceRepresentative half-lifeSources
Midazolam2.5 h3
Temazepam9 h3
Alprazolam11.2 h3
Lorazepam14 h3
Diazepam30 h3
Clonazepam34 h3
Chlordiazepoxide36 h3

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beta blocker

1 profile currently published.

SubstanceRepresentative half-lifeSources
Propranolol4 h3

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cannabinoid

2 profiles currently published.

SubstanceRepresentative half-lifeSources
CBD2.4 days3
THCNo curve published4

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cocaine form

1 profile currently published.

SubstanceRepresentative half-lifeSources
Crack cocaine1 h2

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depressant

4 profiles currently published.

SubstanceRepresentative half-lifeSources
GHB45 min4
1,4-ButanediolNo curve published3
AlcoholNo curve published3
GBLNo curve published3

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dissociative

5 profiles currently published.

SubstanceRepresentative half-lifeSources
Ketamine2.5 h4
Dextromethorphan3.5 h3
PCP21 h4
MXENo curve published3
Nitrous oxideNo curve published4

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dissociative metabolite

1 profile currently published.

SubstanceRepresentative half-lifeSources
Norketamine4 h3

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entactogen

2 profiles currently published.

SubstanceRepresentative half-lifeSources
MDMA8 h5
MDA10 h3

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gabaergic

2 profiles currently published.

SubstanceRepresentative half-lifeSources
KavaNo curve published4
PhenibutNo curve published4

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gabapentinoid

2 profiles currently published.

SubstanceRepresentative half-lifeSources
Gabapentin6 h3
Pregabalin6 h2

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novel benzodiazepine

2 profiles currently published.

SubstanceRepresentative half-lifeSources
BromazolamNo curve published2
FlualprazolamNo curve published2

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opioid

11 profiles currently published.

SubstanceRepresentative half-lifeSources
Heroin6 min3
Morphine2 h4
Hydromorphone2.3 h3
Codeine3 h3
Meperidine3 h3
Oxycodone3.5 h4
Fentanyl3.6 h3
Hydrocodone4 h3
Tapentadol4 h3
Tramadol6 h2
Oxymorphone8 h3

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opioid antagonist

1 profile currently published.

SubstanceRepresentative half-lifeSources
Naloxone2 h3

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opioid combo

1 profile currently published.

SubstanceRepresentative half-lifeSources
Codeine-promethazine syrupNo curve published3

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opioid treatment

2 profiles currently published.

SubstanceRepresentative half-lifeSources
Methadone24 h3
Buprenorphine37 h3

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psychedelic

14 profiles currently published.

SubstanceRepresentative half-lifeSources
DMT10 min3
Psilocybin3 h3
Mescaline3.5 h2
LSD3.6 h4
1P-LSDNo curve published2
25I-NBOMeNo curve published2
2C-BNo curve published2
4-AcO-DMTNo curve published3
5-MeO-DMTNo curve published2
AL-LADNo curve published2
AyahuascaNo curve published4
DPTNo curve published3
MuscimolNo curve published2
Salvia divinorumNo curve published3

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public health adulterant

1 profile currently published.

SubstanceRepresentative half-lifeSources
Xylazine5.8 h4

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sedative hypnotic

2 profiles currently published.

SubstanceRepresentative half-lifeSources
Zolpidem2.5 h2
Zopiclone / Eszopiclone5 h4

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stimulant

11 profiles currently published.

SubstanceRepresentative half-lifeSources
Lisdexamfetamine48 min3
Cocaine1 h4
Nicotine2 h3
Mephedrone2.0 h3
Methylphenidate3 h2
Caffeine5 h3
Amphetamine11 h2
Dextroamphetamine11 h3
Methamphetamine11 h3
Mixed amphetamine salts11.5 h3
Alpha-PVPNo curve published2

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synthetic cannabinoid

1 profile currently published.

SubstanceRepresentative half-lifeSources
MDMB-class synthetic cannabinoidsNo curve published2

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synthetic opioid

5 profiles currently published.

SubstanceRepresentative half-lifeSources
CarfentanilNo curve published2
IsotonitazeneNo curve published2
MetonitazeneNo curve published2
Nitazene opioidsNo curve published4
U-47700No curve published2

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thienodiazepine

1 profile currently published.

SubstanceRepresentative half-lifeSources
Etizolam3.5 h3

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wakefulness promoting

1 profile currently published.

SubstanceRepresentative half-lifeSources
Modafinil15 h4