Amphetamine half-life
The curve uses an 11-hour mixed amphetamine estimate.
Every curve begins at 100%. No dose or measured body concentration is assumed.
X-axis: elapsed time. Y-axis: modeled percentage of the relative starting point remaining. This is a mathematical visualization, not a personal concentration estimate.
Amphetamine: evidence and interpretation notes
What the curve is actually following
The curve uses an 11-hour mixed amphetamine estimate. The useful detail is the separation between d- and l-amphetamine, formulation, urinary pH, and study setting rather than the apparent neatness of the midpoint.
The calculator follows Amphetamine with a 11-hour half-life. That simplification is useful for curve shape and comparison, but it is not an individualized pharmacokinetic estimate.
Amphetamine half-life is a useful example of why urinary pH, formulation, and stereochemistry can matter. A single number can make the curve readable, but it cannot represent every product or person.
The 11 hour value places amphetamine among longer-lasting stimulants in the database. The modeled curve shows persistence of the parent-compound estimate, not alertness, appetite effects, sleep disruption, or safety.
Use the page for pharmacokinetic interpretation only. It is not a guide to medication timing, performance, or misuse.
For Amphetamine, persistence in the model should be separated from alertness, euphoria, appetite change, sleep disruption, and cardiovascular effects. Those outcomes can diverge from parent-drug decline.
What each source contributes
- DailyMed: Mixed amphetamine salts capsule. This product label adds formulation-specific pharmacokinetic context and does not represent every route or product.
- PubChem: Amphetamine. This identity record confirms names and compound identity and does not supply a human half-life.
For Amphetamine, the numerical model is tied most closely to DailyMed: Mixed amphetamine salts capsule. As a product label, it adds formulation-specific pharmacokinetic context; it does not represent every route or product.
Why there is no range on the chart
This profile plots 11 hours for Amphetamine without adding an unsourced high-low band. A single supported center is more honest than manufacturing a range from unrelated routes, populations, or formulations.
InterpretationReading the curve and its category context
Reading this curve
HalfLifeDB uses 11 h as a representative input for Amphetamine. In the simplified model, about 22.0% remains after 24 hours and about 3% remains after five half-lives, or roughly 2.3 days.
This sits in the same-day range. The chart is useful for seeing the bend of the curve across a day or two, but it should not be treated as a personal clock. The curve is relative: it does not estimate a person's measured concentration, effects, impairment, or time to clearance.
stimulant context
Stimulant half-life estimates can shift with urine pH, enzyme activity, formulation, dose, and whether metabolites are measured separately.
- Alertness or subjective stimulation can end before modeled elimination.
- Sleep disruption and downstream effects are not represented by the curve.
- Formulation and route can change peak timing without changing the displayed model.
ComparisonTimeline checkpoints and nearby profiles
Amphetamine timeline checkpoints
| Elapsed time | Modeled remaining | Reading note |
|---|---|---|
| 12 h | 46.9% | Meaningful modeled decline, not near-zero |
| 24 h | 22.0% | Long-tail portion of the model |
| 2.0 days | 4.86% | Low modeled remainder, not a clearance guarantee |
| 3.0 days | 1.07% | Low modeled remainder, not a clearance guarantee |
| 5.0 days | 0.05% | Low modeled remainder, not a clearance guarantee |
Nearby profiles by half-life
These entries sit near Amphetamine within the stimulant group when sorted by representative half-life. That makes them curve comparisons, not statements about equal potency, effects, or risk.
- Caffeine (5 h)
- Dextroamphetamine (11 h)
- Methamphetamine (11 h)
- Methylphenidate (3 h)
EvidencePharmacokinetic inputs and source trail
Pharmacokinetics at a glance
| Representative half-life | 11 h |
|---|---|
| Curve type | Normalized, first-order decline |
Selection note: The curve uses an 11-hour mixed amphetamine estimate. The useful detail is the separation between d- and l-amphetamine, formulation, urinary pH, and study setting rather than the apparent neatness of the midpoint.
Sources and evidence context
A linked record is not automatically proof of the displayed value. Study, labeling, review, and compound identity sources serve different purposes; notes below identify limitations when they are known.
- Official labeling DailyMed label: Mixed amphetamine salts capsule.Official U.S. product labeling used for formulation and labeled pharmacokinetic context; its statements apply to the described product.
- Identity record PubChem Compound Summary: Amphetamine.Compound identity and naming record. It supplies chemistry context, not independent numerical support for the model.
BoundariesWhat this page cannot answer and where to continue
What this page does not answer
- It does not estimate impairment, intoxication, or fitness to drive.
- It does not predict urine, blood, saliva, or hair test results.
- It does not model repeated exposure, tolerance, withdrawal, or interactions.
- It does not replace clinician, pharmacist, toxicologist, or emergency guidance.
Continue with context
- All substance profiles
- Browse the stimulant group
- Compare this curve
- Clearance and volume of distribution
- Bioavailability, route, and formulation
- Active metabolites and parent compounds
- First-order vs nonlinear kinetics
- Detection windows vs half-life
- Reading labels and source quality
Read the medical disclaimer, methodology, and research standards before using the model for comparison.