Profile library
All substance half-life profiles
This index includes the profiles that currently meet HalfLifeDB's publication threshold: a defensible representative value, a readable evidence note, and direct links to the source material used for context.
Showing 18 of 18 reviewed profiles
| Substance | Category | Representative half-life | References |
|---|---|---|---|
| Alprazolam | benzodiazepine | 11.2 hours | 3 |
| Buprenorphine | opioid treatment | 37 hours | 3 |
| Caffeine | stimulant | 5 hours | 3 |
| Cocaine | stimulant | 1 hours | 4 |
| Diazepam · models Diazepam parent compound | benzodiazepine | 30 hours | 3 |
| DMT · models DMT after a 10-minute IV infusion | psychedelic | 10 min | 3 |
| Fluoxetine · models Fluoxetine after chronic administration | antidepressant | 4 days | 3 |
| Gabapentin | gabapentinoid | 6 hours | 3 |
| Ketamine · models Ketamine beta (redistribution) phase | dissociative | 2.5 hours | 4 |
| LSD | psychedelic | 3.6 hours | 4 |
| MDMA | entactogen | 8 hours | 5 |
| Methadone · models Methadone after multiple dosing | opioid treatment | 24 hours | 3 |
| Modafinil · models Modafinil after multiple dosing | wakefulness promoting | 15 hours | 4 |
| Morphine · models Morphine after IV administration | opioid | 2 hours | 4 |
| Nicotine | stimulant | 2 hours | 3 |
| Oxycodone · models Immediate-release oxycodone | opioid | 3.5 hours | 4 |
| Psilocybin · models Psilocin after oral psilocybin | psychedelic | 3 hours | 3 |
| Sertraline | antidepressant | 26 hours | 3 |