Profile library

All substance profiles

This index includes completed substance profiles with direct source links. A profile can publish as an evidence note even when the available human pharmacokinetic evidence does not justify a representative curve.

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Showing 93 of 93 profiles

Substance	Category	Representative half-life	References
1,4-Butanediol	depressant	No curve published	3
1P-LSD	psychedelic	No curve published	2
25I-NBOMe	psychedelic	No curve published	2
2C-B	psychedelic	No curve published	2
4-AcO-DMT	psychedelic	No curve published	3
5-MeO-DMT	psychedelic	No curve published	2
AL-LAD	psychedelic	No curve published	2
Alcohol	depressant	No curve published	3
Alpha-PVP	stimulant	No curve published	2
Alprazolam	benzodiazepine	11.2 hours	3
Amphetamine	stimulant	11 hours	2
Ayahuasca	psychedelic	No curve published	4
Bromazolam	novel benzodiazepine	No curve published	2
Buprenorphine	opioid treatment	37 hours	3
Bupropion	antidepressant	21 hours	3
Caffeine	stimulant	5 hours	3
Carfentanil	synthetic opioid	No curve published	2
CBD · models CBD after repeated oral Epidiolex dosing	cannabinoid	2.4 days	3
Chlordiazepoxide · models Parent chlordiazepoxide	benzodiazepine	36 hours	3
Clonazepam	benzodiazepine	34 hours	3
Clonidine	alpha 2 agonist	12 hours	2
Cocaine	stimulant	1 hours	4
Codeine	opioid	3 hours	3
Codeine-promethazine syrup	opioid combo	No curve published	3
Crack cocaine	cocaine form	1 hours	2
Dextroamphetamine	stimulant	11 hours	3
Dextromethorphan	dissociative	3.5 hours	3
Diazepam · models Diazepam parent compound	benzodiazepine	30 hours	3
Diphenhydramine	antihistamine	9 hours	3
DMT · models DMT after a 10-minute IV infusion	psychedelic	10 min	3
Doxylamine	antihistamine	No curve published	3
DPT	psychedelic	No curve published	3
Escitalopram	antidepressant	30 hours	3
Etizolam	thienodiazepine	3.5 hours	3
Fentanyl · models Fentanyl after intravenous injection	opioid	3.6 hours	3
Flualprazolam	novel benzodiazepine	No curve published	2
Fluoxetine · models Fluoxetine after chronic administration	antidepressant	4 days	3
Gabapentin	gabapentinoid	6 hours	3
GBL	depressant	No curve published	3
GHB	depressant	45 min	4
Heroin	opioid	6 min	3
Hydrocodone	opioid	4 hours	3
Hydromorphone	opioid	2.3 hours	3
Hydroxyzine	antihistamine	No curve published	3
Isotonitazene	synthetic opioid	No curve published	2
Kava	gabaergic	No curve published	4
Ketamine · models Ketamine beta (redistribution) phase	dissociative	2.5 hours	4
Kratom	atypical opioid	23 hours	3
Lisdexamfetamine · models Unconverted lisdexamfetamine in plasma	stimulant	48 min	3
Lorazepam	benzodiazepine	14 hours	3
LSD	psychedelic	3.6 hours	4
MDA	entactogen	10 hours	3
MDMA	entactogen	8 hours	5
MDMB-class synthetic cannabinoids	synthetic cannabinoid	No curve published	2
Meperidine	opioid	3 hours	3
Mephedrone · models Mephedrone after controlled intranasal administration	stimulant	2.0 hours	3
Mescaline · models Parent mescaline in plasma	psychedelic	3.5 hours	2
Methadone · models Methadone after multiple dosing	opioid treatment	24 hours	3
Methamphetamine	stimulant	11 hours	3
Methylphenidate	stimulant	3 hours	2
Metonitazene	synthetic opioid	No curve published	2
Midazolam	benzodiazepine	2.5 hours	3
Mixed amphetamine salts · models Mixed d- and l-amphetamine estimate	stimulant	11.5 hours	3
Modafinil · models Modafinil after multiple dosing	wakefulness promoting	15 hours	4
Morphine · models Morphine after IV administration	opioid	2 hours	4
Muscimol	psychedelic	No curve published	2
MXE	dissociative	No curve published	3
Naloxone · models Intranasal naloxone	opioid antagonist	2 hours	3
Nicotine	stimulant	2 hours	3
Nitazene opioids	synthetic opioid	No curve published	4
Nitrous oxide	dissociative	No curve published	4
Norketamine	dissociative metabolite	4 hours	3
Oxycodone · models Immediate-release oxycodone	opioid	3.5 hours	4
Oxymorphone	opioid	8 hours	3
PCP	dissociative	21 hours	4
Phenibut	gabaergic	No curve published	4
Pregabalin	gabapentinoid	6 hours	2
Propranolol	beta blocker	4 hours	3
Psilocybin · models Psilocin after oral psilocybin	psychedelic	3 hours	3
Quetiapine	antipsychotic	6 hours	3
Salvia divinorum	psychedelic	No curve published	3
Sertraline	antidepressant	26 hours	3
Tapentadol · models Immediate-release parent tapentadol	opioid	4 hours	3
Temazepam	benzodiazepine	9 hours	3
THC	cannabinoid	No curve published	4
Tianeptine	atypical antidepressant	2.5 hours	3
Tramadol	opioid	6 hours	2
Trazodone	antidepressant	7 hours	3
U-47700	synthetic opioid	No curve published	2
Venlafaxine	antidepressant	5 hours	3
Xylazine · models Xylazine in a small opioid-overdose cohort	public health adulterant	5.8 hours	4
Zolpidem	sedative hypnotic	2.5 hours	2
Zopiclone / Eszopiclone · models Zopiclone racemate	sedative hypnotic	5 hours	4