HalfLifeDBEvidence before certainty.

Doxylamine evidence profile

The attached over-the-counter combination label provides product context, while the cited disposition study is in pregnant nonhuman primates.

Category: antihistamine · Updated: August 7, 2026

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Model statusNo curve publishedCurrent sources do not support one defensible human input
Evidence boundarySource note onlyNo animal, forensic, mixture, or proxy value is presented as a human half-life
Model scopeNot modeledThe profile explains what the available records can and cannot establish
References3Linked studies, labels, reviews, or identity records described below

Doxylamine: evidence and interpretation notes

Why HalfLifeDB does not plot Doxylamine

The attached over-the-counter combination label provides product context, while the cited disposition study is in pregnant nonhuman primates. Those records do not cleanly support a general adult human value for doxylamine on their own.

What each source contributes

  • DailyMed: COLD AND FLU DAYTIME, NIGHTTIME, MAXIMUM STRENGTH (ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, GUAIFENESIN, PHENYLEPHRINE HCL) KIT [WALGREEN COMPANY]. This product label adds formulation-specific pharmacokinetic context and does not represent every route or product.
  • PubChem: Doxylamine. This identity record confirms names and compound identity and does not supply a human half-life.
  • Pharmacokinetics of doxylamine given as Bendectin in the pregnant monkey and baboon. This preclinical study documents species-specific disposition or assay work and is not translated into a typical human estimate.

For Doxylamine, the decision to withhold a curve turns on the limits visible in DailyMed: COLD AND FLU DAYTIME, NIGHTTIME, MAXIMUM STRENGTH (ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, GUAIFENESIN, PHENYLEPHRINE HCL) KIT [WALGREEN COMPANY]. This product label adds formulation-specific pharmacokinetic context, but it does not represent every route or product.

What evidence would change the page

The publication threshold for a future Doxylamine model is concrete: serial human plasma data, explicit analyte identification, a described route or preparation, and a reported half-life phase. DailyMed: COLD AND FLU DAYTIME, NIGHTTIME, MAXIMUM STRENGTH (ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, GUAIFENESIN, PHENYLEPHRINE HCL) KIT [WALGREEN COMPANY] remains useful, but it does not cross that threshold.

InterpretationCategory context and evidence limits

antihistamine context

Antihistamine profiles can show a gap between pharmacokinetic persistence and perceived sedation, alertness, or next-day effects.

  • Sedation and anticholinergic effects are not predicted by the curve.
  • Age, co-medications, and formulation can change practical interpretation.
  • Detection, impairment, and safety questions require context beyond half-life.
EvidenceSource trail and model decision

Sources and evidence context

A linked record is not automatically proof of the displayed value. Study, labeling, review, and compound identity sources serve different purposes; notes below identify limitations when they are known.

1 PubMed0 PMC1 DailyMed1 PubChem
  1. Official labeling DailyMed label: COLD AND FLU DAYTIME, NIGHTTIME, MAXIMUM STRENGTH (ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, GUAIFENESIN, PHENYLEPHRINE HCL) KIT [WALGREEN COMPANY].
    Official U.S. product labeling used for formulation and labeled pharmacokinetic context; its statements apply to the described product.
  2. Identity record PubChem Compound Summary: Doxylamine.
    Compound identity and naming record. It supplies chemistry context, not independent numerical support for the model.
  3. Research abstract PubMed: Pharmacokinetics of doxylamine given as Bendectin in the pregnant monkey and baboon.
    Non-human primate study; supplemental context only because product labeling and compound records are also linked.
BoundariesWhat this page cannot answer and where to continue

What this page does not answer

  • It does not estimate impairment, intoxication, or fitness to drive.
  • It does not predict urine, blood, saliva, or hair test results.
  • It does not model repeated exposure, tolerance, withdrawal, or interactions.
  • It does not replace clinician, pharmacist, toxicologist, or emergency guidance.

Continue with context

Read the medical disclaimer, methodology, and research standards before using the model for comparison.