Pregabalin half-life
Pregabalin labeling supports a roughly six-hour elimination half-life and predominantly renal clearance.
Every curve begins at 100%. No dose or measured body concentration is assumed.
X-axis: elapsed time. Y-axis: modeled percentage of the relative starting point remaining. This is a mathematical visualization, not a personal concentration estimate.
Pregabalin: evidence and interpretation notes
What the representative value means
Pregabalin labeling supports a roughly six-hour elimination half-life and predominantly renal clearance. That makes kidney function a more meaningful source of variation than hepatic metabolism for this profile.
For the interactive chart, HalfLifeDB starts with 6 hours as the representative value for Pregabalin. Route, formulation, sampling, and metabolites remain attached to that label instead of being hidden inside the arithmetic.
Pregabalin is a gabapentinoid where renal elimination makes patient context important. A general adult half-life can be misleading when kidney function differs.
The 6 hour value creates a moderate curve for the model. It does not represent dose adjustment, symptom control, or adverse-effect timing.
The citations include a direct DailyMed pregabalin capsule label and the compound record.
Medication decisions require clinician guidance and patient-specific information.
For Pregabalin, renal function is a major interpretive caveat. A standard half-life estimate may not fit people with altered clearance, and the calculator does not adjust for that.
What each source contributes
- DailyMed: Pregabalin capsule. This product label adds formulation-specific pharmacokinetic context and does not represent every route or product.
- PubChem: Pregabalin. This identity record confirms names and compound identity and does not supply a human half-life.
For Pregabalin, the numerical model is tied most closely to DailyMed: Pregabalin capsule. As a product label, it adds formulation-specific pharmacokinetic context; it does not represent every route or product.
Why there is no range on the chart
This profile plots 6 hours for Pregabalin without adding an unsourced high-low band. A single supported center is more honest than manufacturing a range from unrelated routes, populations, or formulations.
InterpretationReading the curve and its category context
Reading this curve
HalfLifeDB uses 6 h as a representative input for Pregabalin. In the simplified model, about 6.3% remains after 24 hours and about 3% remains after five half-lives, or roughly 30 h.
This sits in the same-day range. The chart is useful for seeing the bend of the curve across a day or two, but it should not be treated as a personal clock. The curve is relative: it does not estimate a person's measured concentration, effects, impairment, or time to clearance.
gabapentinoid context
Gabapentinoid half-life estimates often look straightforward, but renal clearance, formulation, and repeated dosing can strongly affect practical interpretation.
- The curve is not a sedation, withdrawal, or dose-adjustment guide.
- Renal function can be central to source interpretation.
- Repeated-use accumulation is not modeled by the single-dose chart.
ComparisonTimeline checkpoints and nearby profiles
Pregabalin timeline checkpoints
| Elapsed time | Modeled remaining | Reading note |
|---|---|---|
| 12 h | 25.0% | Long-tail portion of the model |
| 24 h | 6.25% | Low modeled remainder, not a clearance guarantee |
| 2.0 days | 0.39% | Low modeled remainder, not a clearance guarantee |
| 3.0 days | 0.02% | Low modeled remainder, not a clearance guarantee |
| 5.0 days | 0.00% | Low modeled remainder, not a clearance guarantee |
Nearby profiles by half-life
These entries sit near Pregabalin within the gabapentinoid group when sorted by representative half-life. That makes them curve comparisons, not statements about equal potency, effects, or risk.
- Gabapentin (6 h)
EvidencePharmacokinetic inputs and source trail
Pharmacokinetics at a glance
| Representative half-life | 6 h |
|---|---|
| Curve type | Normalized, first-order decline |
Selection note: Pregabalin labeling supports a roughly six-hour elimination half-life and predominantly renal clearance. That makes kidney function a more meaningful source of variation than hepatic metabolism for this profile.
Sources and evidence context
A linked record is not automatically proof of the displayed value. Study, labeling, review, and compound identity sources serve different purposes; notes below identify limitations when they are known.
- Official labeling DailyMed label: Pregabalin capsule.Official U.S. product labeling used for formulation and labeled pharmacokinetic context; its statements apply to the described product.
- Identity record PubChem Compound Summary: Pregabalin.Compound identity and naming record. It supplies chemistry context, not independent numerical support for the model.
BoundariesWhat this page cannot answer and where to continue
What this page does not answer
- It does not estimate impairment, intoxication, or fitness to drive.
- It does not predict urine, blood, saliva, or hair test results.
- It does not model repeated exposure, tolerance, withdrawal, or interactions.
- It does not replace clinician, pharmacist, toxicologist, or emergency guidance.
Continue with context
- All substance profiles
- Browse the gabapentinoid group
- Compare this curve
- Clearance and volume of distribution
- Bioavailability, route, and formulation
- Active metabolites and parent compounds
- First-order vs nonlinear kinetics
- Detection windows vs half-life
- Reading labels and source quality
Read the medical disclaimer, methodology, and research standards before using the model for comparison.